期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 21, 期 7, 页码 1621-1627出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2013.01.068
关键词
Aminopeptidase N; Inhibitors; Leucine ureido derivatives; Synthesis
资金
- National Science and Technology Specific Projects of China [2011ZX09401-015]
- National Nature Science Foundation of China [21172134]
Aminopeptidase N (APN/CD13) over expressed on tumor cells, plays a critical role in tumor invasion, metastasis, and tumor angiogenesis. Here we described the design, synthesis and preliminary activity studies of novel leucine ureido derivatives as aminopeptidase N (APN/CD13) inhibitors. The results showed that compound 8c had the most potent inhibitory activity against APN with the IC50 value to 0.06 +/- 0.041 mu M, which could be used for further anticancer agent research. (C) 2013 Elsevier Ltd. All rights reserved.
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