期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 21, 期 11, 页码 2912-2917出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2013.03.078
关键词
Marine natural products; Sponge; Carteriospongia; Homoscalarane; Sesterterpenes; Antiproliferative activity; Nuclear magnetic resonance
资金
- Fogarty International Center
- National Cancer Institute
- National Science Foundation
- National Heart, Lung and Blood Institute
- National Institute of Mental Health
- Office of Dietary Supplements
- Office of the Director of NIH [U01 TW000313]
- International Cooperative Biodiversity Groups
- National Research Initiative of the Cooperative State Research, Education and Extension Service, USDA [2008-35621-04732]
- National Science Foundation [CHE-0619382, CHE-0722638]
Dereplication of the antiproliferative ethyl acetate fraction of the Madagascan sponge Carteriospongia sp. led to the detection and isolation of the two known homoscalarane-type sesterterpenes 1 and 2. Investigation of a similar sponge containing closely related compounds afforded the four new antiproliferative homoscalarane sesterterpenes (3 and 5-7). The structures of all isolated compounds were elucidated by spectroscopic methods, including UV, IR and 1D and 2D NMR. Compounds 1, 3 and 5 displayed submicromolar antiproliferative activity against the A2780 ovarian cell line with IC50 values of 0.65, 0.26 and 0.28 mu M, respectively, while compounds 6 and 7 showed moderate activity (4.5 and 8.7 mu M, respectively). Compounds 3 and 5 also displayed anti-proliferative activity against the H522-T1 non-small cell lung and A2058 human melanoma cancer cell lines. (C) 2013 Elsevier Ltd. All rights reserved.
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