期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 20, 期 21, 页码 6237-6247出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2012.09.010
关键词
Bioorthogonal conjugation; Click chemistry; Ligand design; Medicinal chemistry; Photoaffinity labeling
Photoaffinity labeling has a longstanding history as a powerful biochemical technique. However, photoaffinity labeling has significantly evolved over the past decade principally due to its coupling with bioorthogonal/click chemistry reactions. This review aims to highlight tandem photoaffinity labeling-bioorthogonal conjugation as a chemical approach in medicinal chemistry and chemical biology. In particular, recent examples of using this strategy for affinity-based protein profiling (AfBPP), drug target identification, binding ensemble profiling, studying endogenous biological molecules, and imaging applications will be presented. Additionally, recent advances in the development of 'all-in-one' compact moieties possessing a photoreactive group and clickable handle will be discussed. (C) 2012 Elsevier Ltd. All rights reserved.
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