期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 20, 期 20, 页码 6134-6143出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2012.08.017
关键词
Cyanobactreia; Anabaena; Cyclic lipopeptides; MDA-MB-435; Antiproliferative activity
资金
- NCI/NIH [PO1 CA125066]
The extract of UIC 10035, a strain obtained from a sample collected near the town of Homestead, South Florida, showed antiproliferative activity against MDA-MB-435 cells. Bioassay-guided fractionation led to the isolation of a series of cyclic lipodecapeptides, named minutissamides E-L (1-8). The planar structures were determined by analysis of HRESIMS, tandem MS, and 1D and 2D NMR data, and the stereo-configurations were assigned by LC-MS analysis of the Marfey's derivatives after acid hydrolysis. Minutissamides E-L (1-8) exhibited antiproliferative activity against MDA-MB-435 cells with IC50 values ranging between 1 and 10 mu M. The structures of minutissamides E-L (1-8) were closely related with those of the previously reported lipopeptides, puwainaphycins A-E and minutissamides A-D, characterized by the presence of a lipophilic beta-amino acid and three non-standard amino acids NMeAsn, OMeThr and Dhb (alpha,beta-dehydro-alpha-aminobutyric acid). The strain UIC 10035 was designated as cf. Anabaena sp. on the basis of morphological and 16S rRNA gene sequence analyses. (C) 2012 Elsevier Ltd. All rights reserved.
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