期刊
FEMS MICROBIOLOGY REVIEWS
卷 45, 期 5, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/femsre/fuab014
关键词
enteric fever; typhoid; Salmonella Typhi; Salmonella Paratyphi A; bacterial pathogenesis; enteric infection
类别
资金
- NIHR Oxford Biomedical Research Centre
This review summarizes the advances in understanding the pathogenesis of enteric fever, including mechanisms of host restriction, intestinal invasion, interactions with innate immunity, and chronic carriage, and discusses how this knowledge may advance future vaccines and antimicrobials.
While conjugate vaccines against typhoid fever have recently been recommended by the World Health Organization for deployment, the lack of a vaccine against paratyphoid, multidrug resistance and chronic carriage all present challenges for the elimination of enteric fever. In the past decade, the development of in vitro and human challenge models has resulted in major advances in our understanding of enteric fever pathogenesis. In this review, we summarise these advances, outlining mechanisms of host restriction, intestinal invasion, interactions with innate immunity and chronic carriage, and discuss how this knowledge may progress future vaccines and antimicrobials. In this review the authors summarise advances in the understanding of enteric fever pathogenesis, outlining mechanisms of host restriction, intestinal invasion, interactions with innate immunity and chronic carriage.
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