期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 19, 期 12, 页码 3690-3701出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2011.01.013
关键词
Histone acetyltransferases modulators; p300/CBP; PCAF activator; KAT; Epigenetics
资金
- Ministero dell'Universita e della Ricerca Scientifica e Tecnologica
- Fondazione Roma
- Universita di Salerno, Italy
- ATLAS [HEALTH-F4-2009-221952]
- Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom
A novel class of KAT modulators (long chain alkylidenemalonates, LoCAMs) has been identified. Variations of the alkyl chain length can change the activity profile from inhibition of both KAT3A/KAT2B (as derivative 2a) to the peculiar profile of pentadecylidenemalonate 1b, the first activator/inhibitor of histone acetyltransferases. Together with the powerful apoptotic effect (particularly notable if considering that anacardic acid and other KAT inhibitors are not cell permeable) appoint them as valuable biological tools to understand the mechanisms of lysine acetyltransferases. (C) 2011 Elsevier Ltd. All rights reserved.
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