4.7 Article

Identification of novel ASK1 inhibitors using virtual screening

期刊

BIOORGANIC & MEDICINAL CHEMISTRY
卷 19, 期 1, 页码 486-489

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2010.11.004

关键词

ASK1; Virtual screening; Chemical library

资金

  1. Ministry of Education, Culture, Sports, Science, and Technology of Japan

向作者/读者索取更多资源

Apoptosis signal-regulating kinase 1 (ASK1, also called MAP3K5) is a mitogen-activated protein kinase kinase kinase (MAP3K) that plays important roles in stress-induced cell death and inflammation, and is expected as a new therapeutic target for cancer, cardiovascular diseases, and neurodegenerative diseases. We identified novel ASK1 inhibitors by virtual screening from the public chemical library collected by Chemical Biology Research Initiative (CBRI) at the University of Tokyo. (C) 2010 Elsevier Ltd. All rights reserved.

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