期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 19, 期 1, 页码 486-489出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2010.11.004
关键词
ASK1; Virtual screening; Chemical library
资金
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
Apoptosis signal-regulating kinase 1 (ASK1, also called MAP3K5) is a mitogen-activated protein kinase kinase kinase (MAP3K) that plays important roles in stress-induced cell death and inflammation, and is expected as a new therapeutic target for cancer, cardiovascular diseases, and neurodegenerative diseases. We identified novel ASK1 inhibitors by virtual screening from the public chemical library collected by Chemical Biology Research Initiative (CBRI) at the University of Tokyo. (C) 2010 Elsevier Ltd. All rights reserved.
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