期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 19, 期 16, 页码 4876-4881出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2011.06.067
关键词
Peltodon longipes; Salvia miltiorrhiza; Lamiaceae; Abietane diterpenes; Cytotoxicity; MIAPaCa-2; MV-3; Structure-activity relationship
资金
- government of Baden-Wurttemberg (Zukunftsoffensive IV)
Phytochemical investigations of the n-hexane extract from the roots of Peltodon longipes (Lamiaceae) resulted in the isolation of 12 known abietane diterpenes (1-12). Structures were established on the basis of one and two dimensional nuclear magnetic resonance spectroscopic data (H-1 and C-13, COSY, HSQC and HMBC), electron ionization mass spectrometric analysis (EIMS) as well as comparison with data from literature. These compounds, as well as eight known diterpenes (13-19) from Salvia miltiorrhiza, and two from Salvia sahendica (20 and 21) were evaluated for their cytotoxic effects in human pancreatic (MIAPaCa-2) and melanoma (MV-3) tumor cell lines using the MTT assay. Tanshinone IIa (13), 7 alpha-acetoxyroyleanone (1), 1,2-dihydrotanshinone (16) and cryptotanshinone (14) had the highest cytotoxic effects in MIAPaCa-2, displaying IC50 of 1.9, 4.7, 5.6, and 5.8 mu M, respectively. Structure-activity relationships of abietane diterpenoid quinones are discussed. (C) 2011 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据