期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 19, 期 21, 页码 6254-6260出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2011.09.013
关键词
Gynostemma pentaphyllum (Gp); Damulins A and B; AMP-activated protein kinase (AMPK)
资金
- Plant Diversity Research Center [PF06212-00]
- Ministry of Science and Technology
- Korean government
AMP-activated protein kinase (AMPK) is a key sensor and regulator of glucose, lipid, and energy metabolism throughout the body. Activation of AMPK improves metabolic abnormalities associated with metabolic diseases including obesity and type-2 diabetes. The oriental traditional medicinal herbal plant, Gynostemma pentaphyllum, has shown a wide range of beneficial effects on glucose and lipid metabolism. In this study, we found that G. pentaphyllum contains two novel dammarane-type saponins designated as damulin A (1), 2 alpha,3 beta,12 beta-trihydroxydammar-20(22)-E, 24-diene-3-O-[beta-D-glucopyranosyl-(1 -> 2)-beta-D-glucopyranoside], and damulin B (2), 2 alpha,3 beta,12 beta-trihydroxydammar-20,24-diene-3-O-[beta-D-glucopyranosyl-(1 -> 2)-beta-D-glucopyranoside], that strongly activate AMPK in cultured L6 myotube cells. Damulins A and B also increased beta-oxidation and glucose uptake with increasing GluT4 translocation to the plasma membrane in L6 myotube cells. Taken together our results indicate that activation of AMPK by damulins A and B may contribute to beneficial effect of G. pentaphyllum on glucose and lipid metabolism. (C) 2011 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据