期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 19, 期 1, 页码 406-413出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2010.11.011
关键词
Plant growth regulator; P450 inhibitor; ABA
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [22580118]
- Grants-in-Aid for Scientific Research [22580118] Funding Source: KAKEN
We developed abscinazole-E1 (Abz-E1), a specific inhibitor of abscisic acid (ABA) 8'-hydroxylase (CYP707A). This inhibitor was designed and synthesized as an enlarged analogue of uniconazole (UNI), a well-known plant growth retardant, which inhibits a gibberellin biosynthetic enzyme (ent-kaurene oxidase, CYP701A) as well as CYP707A. Our results showed that Abz-E1 functions as a potent inhibitor of CYP707A and a poor inhibitor of CYP701A both in vitro and in vivo. Abz-E1 application to plants resulted in improved desiccation tolerance and an increase in endogenous ABA. (C) 2010 Elsevier Ltd. All rights reserved.
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