期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 19, 期 6, 页码 1972-1977出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2011.01.061
关键词
Guanidine; Oligonucleotide conjugates; Spermine oligomer; Solid phase synthesis
Solid phase spermine oligomerization via guanidine linkers was achieved using activated thiourea coupling reaction with primary amino group. Disymmetric spermine synthon was efficiently synthesised in eight steps from spermine. MMT group was used as coupling monitor and resulting oligomeric spermines were conjugated to oligonucleotides. (C) 2011 Elsevier Ltd. All rights reserved.
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