期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 19, 期 23, 页码 7120-7128出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2011.09.062
关键词
Pyridopyrazine; Pyrimidothiazine; FtsZ inhibitor; Antitubercular
资金
- National Institutes of Health [1R01AI50470]
- TB through Dr. Anne Lenaerts at Colorado State University (NIAID) [NO1 Al-95385]
A series of pyridopyrazine and pyrimidothiazine derivatives have been synthesized and their activity against FtsZ from Mycobacterium tuberculosis (Mtb) and in vitro antibacterial activity against Mtb H37Ra and Mtb H(37)Rv are reported. Certain analogs described herein showed moderate to good inhibitory activity. (C) 2011 Elsevier Ltd. All rights reserved.
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