期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 18, 期 2, 页码 573-579出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2009.12.012
关键词
Enzyme inhibitor; Placental Alkaline Phosphatase; Cancer; Oncodevelopmental
资金
- NIH [U54HG003916, DE12889, 1X01MH077602-01]
Placental Alkaline Phosphatase (PLAP) is a tissue-restricted isozyme of the Alkaline Phosphatase (AP) superfamily. PLAP is an oncodevelopmental enzyme expressed during pregnancy and in a variety of human cancers, but its biological function remains unknown. We report here a series of catechol compounds with great affinity for the PLAP isozyme and significant selectivity over other members of the AP superfamily. These selective PLAP inhibitors will provide small molecule probes for the study of the pathophysiological role of PLAP. (C) 2009 Elsevier Ltd. All rights reserved.
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