期刊
EUROPEAN HEART JOURNAL
卷 42, 期 45, 页码 4656-4668出版社
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/ehab449
关键词
Ischaemic heart disease; Coronary physiology; Fractional flow reserve; Functional optimization; PCI Optimization
资金
- Golden Jubilee National Hospital (NHS National Waiting Times Centre Board)
- British Heart Foundation Research Excellence Awards [RE/18/6/34217]
- Golden Jubilee Research Institute (NHS National Waiting Times Centre Board)
The TARGET-FFR trial examined the importance of FFR value >= 0.90 after PCI, finding that an FFR-guided optimization strategy did not significantly increase this proportion, but did reduce the proportion of patients with FFR value <= 0.80.
Aims A fractional flow reserve (FFR) value >= 0.90 after percutaneous coronary intervention (PCI) is associated with a reduced risk of adverse cardiovascular events. TARGET-FFR is an investigator-initiated, single-centre, randomized controlled trial to determine the feasibility and efficacy of a post-PCI FFR-guided optimization strategy vs. standard coronary angiography in achieving final post-PCI FFR values >= 0.90. Methods and results After angiographically guided PCI, patients were randomized 1:1 to receive a physiology-guided incremental optimization strategy (PIOS) or a blinded coronary physiology assessment (control group). The primary outcome was the proportion of patients with a final post-PCI FFR >= 0.90. Final FFR <= 0.80 was a prioritized secondary outcome. A total of 260 patients were randomized (131 to PIOS, 129 to control) and 68.1% of patients had an initial post-PCI FFR <0.90. In the PIOS group, 30.5% underwent further intervention (stent post-dilation and/or additional stenting). There was no significant difference in the primary endpoint of the proportion of patients with final post-PCI FFR >= 0.90 between groups (PIOS minus control 10%, 95% confidence interval -1.84 to 21.91, P = 0.099). The proportion of patients with a final FFR <= 0.80 was significantly reduced when compared with the angiography-guided control group (-11.2%, 95% confidence interval -21.87 to -0.35], P = 0.045). Conclusion Over two-thirds of patients had a physiologically suboptimal result after angiography-guided PCI. An FFR-guided optimization strategy did not significantly increase the proportion of patients with a final FFR >= 0.90, but did reduce the proportion of patients with a final FFR <= 0.80.
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