期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 18, 期 21, 页码 7580-7585出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2010.08.047
关键词
Benzoxazoles; 5-LOX inhibitors; Airway hypersensitiveness
资金
- Ministry of Knowledge Economy in Korea [NBM1200513]
5-Lipoxygenase (5-LOX) is important enzyme in the biosynthesis of leukotrienes, and is a potential target in the treatment of asthma and allergy. We designed and synthesized a series of benzoxazoles and benzothiazoles as 5-LOX inhibitors. Fourteen compounds prepared showed the inhibition of LTC4 formation with IC50 value of 0.12-23.88 mu M. Also two compounds 2d and 2g showed improved airway hypersensitiveness. (C) 2010 Elsevier Ltd. All rights reserved.
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