期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 18, 期 15, 页码 5466-5474出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2010.06.052
关键词
Marine sponge; Iotrochota baculifera; Baculiferins A-O; HIV-1 target proteins; HIV-1 IIIB virus
资金
- National Hi-Tech Development Project (863 project) [2006DFA31100, 2007AA09Z448, 2008AA09Z405]
- NSFC [30930109]
- National Key Innovation Project [2009ZX09501-014, DYXM-115-02-2-09]
- Deutsche Forschungsgemeinschaft [SFB 630]
Fifteen new DOPA-derived pyrrole alkaloids, named baculiferins A-O (2-16), were isolated from the Chinese marine sponge Iotrochota baculifera, together with the known alkaloids purpurone (1) and ningalin A (17). Most of the new compounds contain one to three O-sulfate units. Their structures were determined by extensive spectroscopic analysis including (1)H and (13)C NMR (COSY, HMQC, HMBC) and ESIMS data. A possible pathway for the biosynthetic origin of the isolated alkaloids is proposed, in which DOPA is assumed to be a joint biogenetic precursor. Baculiferins C, E-H, and K-N (4, 6-9, 12-15) were found to be potent inhibitors against the HIV-1 IIIB virus in both, MT4 and MAGI cells. Additional bioassay revealed that baculiferins could dramatically bind to the HIV-1 target proteins Vif, APOBEC3G, and gp41, for which structure-activity relationships are discussed. (C) 2010 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据