期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 18, 期 1, 页码 242-248出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2009.10.058
关键词
Dendrimer; Galcer; Galactosylceramide
资金
- The European Community
The synthesis and characterization of a new series of catanionic multivalent analogs of GalCer is described. These systems are based on phosphonic acid terminated dendrimers and N-hexadecylamino lactitol moieties. Despite important structural differences that affect the dendrimers' outer-shell, these supramolecular assemblies showed a fairly comparable anti-HIV-1 activity. All compounds have submicromolar IC50 in a cell-based HIV-infection model but also a high general cytotoxicity. (C) 2009 Elsevier Ltd. All rights reserved.
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