期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 17, 期 7, 页码 2894-2901出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2009.02.013
关键词
Isoquinolinquinones; Substitution; Half-wave potential; Cytotoxicity
资金
- Fondo Nacional de Ciencia y Tecnologia [1060591]
A variety of 7-aminoisoquinoline-5,8-quinone derivatives were prepared from 2,5-dihydroxyacetophenone, methyl aminocrotonate, and the corresponding amines, through a highly efficient three-step sequence. The members of this series were tested on normal human fibroblasts and on a panel of three human cancer cell lines and their redox properties were determined by cyclic voltammetry in acetonitrile. Both the cytotoxicity and antitumor activity of 7-phenylaminoisoquinoline-5,8-quinone derivatives showed correlation with their half wave potentials and lipophilicities. (C) 2009 Elsevier Ltd. All rights reserved.
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