期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 17, 期 11, 页码 3795-3799出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2009.04.042
关键词
Phthalimide derivatives; Antimycobacterial; Antitubercular activity; Cytotoxicity
资金
- Funda ao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [07/54983-4, 07/561150, 08/10390-2]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [08/10390-2] Funding Source: FAPESP
New phthalimide derivatives were easily prepared through condensation of phthalic anhydride and selected amines with variable yields (70-90%). All compounds (3a-l) were evaluated against Mycobacterium tuberculosis H(37)Rv using Alamar Blue susceptibility. The compounds 3c, 3i, and 3l have the minimum inhibitory concentrations (MICs) of 3.9, 7.8, and 5.0 mu/mL, respectively, and could be considered new lead compounds in the treatment of tuberculosis and multi-drug resistant tuberculosis. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.
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