期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 17, 期 10, 页码 3698-3712出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2009.03.064
关键词
Phytoalexins; Spiroindolines; Anticancer activity; QSAR
资金
- Slovak Research and Development Agency [APVV-0514-06]
- Slovak Grant Agency for Science [1/3553/06]
- State NMR Programme [2003SP200280203]
New analogs of indole phytoalexin 1-methoxyspirobrassinol methyl ether have been designed by replacement of its 2-methoxy group with 2-(substituted phenyl)amino group. Synthesized by spirocyclization methodology, trans- and cis-diastereoisomers of target compounds were isolated and evaluated as potential anticancer and antimicrobial agents. Their molecular geometries were refined by ab initio minimizations. Pharmacophore modeling and QSAR studies were performed in order to correlate their molecular structure and biological activity. (C) 2009 Elsevier Ltd. All rights reserved.
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