期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 17, 期 2, 页码 600-605出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2008.11.077
关键词
Cancer preventive agent; Isosteviol; Steviol; Stevioside
资金
- Frontier Research Program of the Ministry of Education Science, and Culture of Japan
- NIH [CA-17625]
- National Cancer Institute
- National Institute of General Medical Sciences [GM-76152]
In a search for potential cancer chemopreventive agents from natural resources, stevioside (1), a sweetener, and six related compounds, including two aglycones steviol (6) and isosteviol (7), were screened in an in vitro assay for inhibitory effects on Epstein-Barr virus early antigen activation. Compounds 1, 6 and 7 showed significant activity in this assay and also exhibited strong inhibitory effects in a two-stage carcinogenesis test using mouse skin induced by 7,12-dimethylbenz[a]anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA). The inhibitory effects of these three compounds were greater than that of glycyrrhizin. Furthermore, these three compounds significantly inhibited mouse skin carcinogenesis initiated by peroxynitrite and promoted by TPA. Their activities were comparable to that of curcumin. These results suggested that 1, as well as 6 and 7, could be valuable as chemopreventive agents for chemical carcinogenesis. (C) 2008 Elsevier Ltd. All rights reserved.
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