期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 17, 期 20, 页码 7398-7404出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2009.07.014
关键词
N-Cinnamoyl-L-aspartic acid derivatives; Synthesis; Aminopeptidase N inhibitors
资金
- National Nature Science Foundation of China [30772654, 90713041]
- Ministry of Education of PR China [20060422029]
- National High Technology Research and Development Program of China [2007AA02Z314]
A series of novel derivatives of N-cinnamoyl-L-aspartic acid were designed, synthesized, and assayed for their inhibitory activities against aminopeptidase N. The preliminary biological assay showed that compound 8c has the most potent inhibitory activity against APN with an IC50 of 11.1 +/- 0.9 mu M, this could be used as the lead compound in future research on anticancer agents. (c) 2009 Elsevier Ltd. All rights reserved.
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