期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 17, 期 13, 页码 4537-4541出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2009.05.004
关键词
Eunicella cavolini; 9,11-Secosterols; Structure elucidation; Antiproliferative activity
资金
- University of Athens
Four new 9,11-secosterols (2, 4-6), along with two previously reported ones (1, 3) were isolated from the organic extract of the gorgonian Eunicella cavolini. The structures and relative configurations of the isolated natural products were established on the basis of detailed NMR spectroscopic analysis. Metabolites 1 and 2 were found to strongly inhibit the growth of LNCaP human prostate adenocarcinoma cells and the estrogen-dependent growth of MCF-7 human breast adenocarcinoma cells. (C) 2009 Elsevier Ltd. All rights reserved.
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