期刊
JOURNAL OF CELLULAR BIOCHEMISTRY
卷 116, 期 11, 页码 2577-2588出版社
WILEY
DOI: 10.1002/jcb.25202
关键词
PIPERINE; T LYMPHOCYTE; CELL CYCLE; CYTOKINES; CYTOTOXICITY; SIGNAL TRANSDUCTION
资金
- Canadian Institutes of Health Research
- Crohn's and Colitis Foundation of Canada
- Nova Scotia Health Research Foundation
- Natural Sciences and Engineering Research Council
Piperine is a major alkaloid component of black pepper (Piper nigrum Linn), which is a widely consumed spice. Here, we investigated the effect of piperine on mouse T lymphocyte activation. Piperine inhibited polyclonal and antigen-specific T lymphocyte proliferation without affecting cell viability. Piperine also suppressed T lymphocyte entry into the S and G(2)/M phases of the cell cycle, and decreased expression of G(1)-associated cyclin D3, CDK4, and CDK6. In addition, piperine inhibited CD25 expression, synthesis of interferon-, interleukin (IL)-2, IL-4, and IL-17A, and the generation of cytotoxic effector cells. The inhibitory effect of piperine on T lymphocytes was associated with hypophosphorylation of Akt, extracellular signal-regulated kinase, and inhibitor of B, but not ZAP-70. The ability of piperine to inhibit several key signaling pathways involved in T lymphocyte activation and the acquisition of effector function suggests that piperine might be useful in the management of T lymphocyte-mediated autoimmune and chronic inflammatory disorders. J. Cell. Biochem. 116: 2577-2588, 2015. (c) 2015 Wiley Periodicals, Inc.
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