期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 17, 期 15, 页码 5676-5682出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2009.06.010
关键词
Lignans; Oxidation; Methyltrioxorhenium; Antioxidant activity; Apoptogenic activity
资金
- Interuniversity Consortium 'Chemistry for the Environment' (INCA)
- PNR-FIRB
- ASI and EU COST CM07035 System
- Academy of Finland
Highly oxidized lignans produced during the cytochrome P-450 metabolism in the cells show biological activities significantly different from those of their parent natural compounds. Lignans precursors of mammalian enterolignans were treated with a methyltrioxorhenium/hydrogen peroxide catalytic system to afford new compounds oxidized at benzylic as well as in arylic positions. The evaluation of the antioxidant and apoptogenic activity by in vivo protocols of these compounds showed some interesting structure-activity relationships related to the oxidation degree of the molecules. (C) 2009 Elsevier Ltd. All rights reserved.
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