期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 17, 期 2, 页码 523-529出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2008.11.072
关键词
Amsacrine analogs; Pyranoquinoline; Anticancer drugs; DNA
资金
- University of Padova (Italy)
- Italian Ministry for University and Research (MIUR), Rome (Italy)
A new series of N-[4-(2'-oxo-2H-pyrano[2,3-b]quinolin-5'-ylamino)-phenyl]-methanesulfonamides was prepared and analyzed as novel amsacrine-like derivatives. Our preliminary biological evaluation has shown that the replacement of the acridine moiety with the analogous 2-oxo-2H-pyrano[2,3-b]quinoline system drastically reduced both their anticancer activity and their propency to intercalate into double stranded DNA. (C) 2008 Elsevier Ltd. All rights reserved.
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