期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 17, 期 6, 页码 2290-2303出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2008.10.089
关键词
Total synthesis; Natural products; Drug discovery; Antitumor; Antibiotic
资金
- NCI NIH HHS [R01 CA100101, R01 CA100101-03] Funding Source: Medline
- NIAID NIH HHS [R01 AI055475, R01 AI055475-06] Funding Source: Medline
- NIEHS NIH HHS [R01 ES013314, R01 ES013314-03] Funding Source: Medline
Natural products possess a broad diversity of structure and function, and they provide inspiration for chemistry, biology, and medicine. In this review article, we highlight and place in context our laboratory's total syntheses of, and related studies on, complex secondary metabolites that were clinically important drugs, or have since been developed into useful medicines, namely amphotericin B (1), calicheamicin gamma(I)(1) (2), rapamycin (3), Taxol (R) (4), the epothilones [e.g., epothilones A (5) and B (6)], and vancomycin (7). We also briefly highlight our research with other selected inspirational natural products possessing interesting biological activities [i.e., dynemicin A (8), uncialamycin (9), eleutherobin (10), sarcodictyin A (11), azaspiracid-1 (12), thiostrepton (13), abyssomicin C (14), platensimycin (15), platencin (16), and palmerolide A (17)]. (C) 2008 Elsevier Ltd. All rights reserved.
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