期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 17, 期 3, 页码 1361-1369出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2008.12.009
关键词
Natural product; Antifungal agent; Cyclic depsipeptide; Candida albicans fitness test (CaFT); Genome-wide target based screening
We isolated a cyclic lipodepsipeptide, phomafungin, from a Phoma sp. The distinct antifungal activity of phomafungin in the crude extract was initially discovered by mechanistic pro. ling in the Candida albicans. fitness test. The purified compound contains a 28 member ring consisting of eight amino acids and a beta-hydroxy-gamma-methyl-hexadecanoic acid, and displays a broad spectrum of antifungal activity against Candida spp., Aspergillus fumigatus and Trichophyton mentagrophytes with MIC of 2-8 mu g/ml, and toxicity to mice at 25 mg/kg. The linear peptide derived from opening of the lactone ring was devoid of antifungal activity as well as toxicity. Phomafungin has been identified in a number of Phoma spp. collected from Africa and the Indian and Pacific Ocean islands. (c) 2009 Elsevier Ltd. All rights reserved.
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