期刊
CURRENT ONCOLOGY
卷 29, 期 5, 页码 3647-3657出版社
MDPI
DOI: 10.3390/curroncol29050293
关键词
CAR T cells; CAR NK cells; CLL
类别
资金
- Ministry of Education, Science and Technological Development of the Republic of Serbia [ON175069]
- Serbian bilateral project with PR China [06/2018]
- Faculty of Medical Sciences, University of Kragujevac [JP 17/19]
CAR T cell therapy has shown remarkable success in B-cell leukemia and lymphoma, but has had less success in chronic lymphocytic leukemia (CLL) patients. This review discusses the published results of CAR T cell therapy in CLL, possible mechanisms of failures, and expected developments in the field.
Chimeric antigen receptor T (CAR T) cell therapy achieved remarkable success in B-cell leukemia and lymphoma which led to its incorporation in treatment protocols for these diseases. CAR T cell therapy for chronic lymphocytic leukemia (CLL) patients showed less success compared to other malignant tumors. In this review, we discuss the published results regarding CAR T cell therapy of CLL, possible mechanisms of failures and expected developments.
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