期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 17, 期 9, 页码 3342-3351出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2009.03.041
关键词
MAPKAP-K2; MK2; TNF; Squarate
资金
- U. S. Department of Energy, Office of Science, Office of Basic Energy Sciences [W-31-109-Eng-38]
A novel series of inhibitors for mitogen activated protein kinase-activated protein kinase 2 (MK-2) are reported. These squarate based inhibitors were identified via a high-throughput screen. An MK2 co-structure with the starting ligand was obtained and a structure based approach was followed to optimize potency and selectivity. (C) 2009 Elsevier Ltd. All rights reserved.
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