期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 17, 期 13, 页码 4569-4574出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2009.05.001
关键词
6H-[1]Benzothiopyrano[43-b]quinolines; Synthesis; Anti-HBV agents
A series of novel 6H-[1]benzothiopyrano[4,3-b]quinoline derivatives were prepared and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in human hepatoblastoma-derived liver Hep-G2 cells. Compounds 10g, 10h, 10j, 10l and 10o were found to be potent anti-HBV compounds with IC50 values less than 50 mu M. The most promising compound was 10l, with an IC50 value of 14.7 mu M and a SI value of 12.4. This is the first report of the anti-HBV effects of 6H-[1]benzothiopyrano[4,3-b] quinolin-9-ols. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.
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