Influencing Mechanism of Nod-Like Receptor Protein 3 Inflammasome Activation in A375 Cell Activity in Human Cutaneous Malignant Melanoma

Article Medicine, Research & Experimental

Incidence and Mortality of Malignant Melanoma in Relation to Dermatologist Density in Bavaria

Konstantin Drexler et al.

Summary: There is a significant correlation between dermatologist density in Bavaria and the incidence of malignant melanoma, but no correlation with mortality. Despite an increase in incidence, mortality did not rise in the respective administrative regions.

ADVANCES IN THERAPY (2021)

添加到收藏夹

Article Immunology

S-Variant SARS-CoV-2 Lineage B1.1.7 Is Associated With Significantly Higher Viral Load in Samples Tested by TaqPath Polymerase Chain Reaction

Michael Kidd et al.

Summary: Analysis of recent test data shows that samples containing the SARS-CoV-2 variant B1.1.7 with mutation Delta 69/70 exhibit S gene target failure (SGTF) in ThermoFisher TaqPath RT-qPCR. Samples with SGTF profile are more likely to have higher viral loads, indicating higher infectivity and rapid spread of this variant.

JOURNAL OF INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Effect of hypoxia factors gene silencing on ROS production and metabolic status of A375 malignant melanoma cells

Ivana Spakova et al.

Summary: Malignant melanoma cells can survive persistent stress by utilizing distinct cancerous signaling pathways and transcription factors to regulate the expression of survival genes, leading to changes in cellular metabolism and ultimately apoptosis.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Article Cell Biology

LncRNA-HOTAIR promotes endothelial cell pyroptosis by regulating the miR-22/NLRP3 axis in hyperuricaemia

Kun Chi et al.

Summary: The study revealed that in hyperuricemia, lncRNA-HOTAIR regulates NLRP3 expression by competitively binding miR-22, promoting endothelial cell pyroptosis.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

添加到收藏夹

Article Medicine, Research & Experimental