Petiolins A-C, phloroglucinol derivatives from Hypericum pseudopetiolatum var. kiusianum

Two new phloroglucinol derivatives possessing chromane skeleton, petiolins A ( 1) and B ( 2), and a new phloroglucinol derivative containing a dihydrofuran ring, petiolin C ( 3), were isolated from aerial parts of Hypericum pseudopetiolatum var. kiusianum. The gross structures of 1-3 were elucidated by spectroscopic data, and the relative stereochemistry of 3 was elucidated by NOESY data. Petiolins A-C (1-3) showed modest cytotoxicity, while petiolin C ( 3) exhibited antifungal activity. (C) 2008 Elsevier Ltd. All rights reserved.