期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 16, 期 21, 页码 9536-9545出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2008.09.027
关键词
Antiviral drugs; Human cytomegalovirus (HCMV); Varicella-zoster virus (VZV); Imidazo[1,2-a]pyridine
资金
- Belgian Fonds voor Wetenschappelijk Onderzoeck (FWO), Vlaanderen
- Geconcerteerde Onderzoeksacties (GOA)
- Vlaamse Gemeenschap
The synthesis of original imidazo[1,2-a]pyridines bearing a thioether side chain at the 3 position and diversely substituted on the 6 or 8 position, and their antiviral activities are reported. From the synthesized compounds, the imidazo[1,2-a]pyridines bearing a 5 membered heterocycle (thiophene, furane or pyrrole) in the 6 position or a phenylthio group in the 6 or 8 position (14, 16, 21, 28, 45) were the most potent against human cytomegalovirus (CMV) and varicella-zoster virus (VZV), whereas several other congeners (i. e., 22, 29 and 39), while less potent, were more selective in their inhibitory activity against VZV and CMV. These compounds showed similar activity against thymidine kinase competent (TK+) and deficient (TK ) VZV strains, demonstrating a mechanism of action independent of the viral thymidine kinase. (C) 2008 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据