Microhole fiber-optic sensors for nanoliter liquid measurement

This article reviews the development of nanoliter liquid sensors based on microhole fiber. To measure liquid characteristics in microscale is crucial in the field of environmental pollution monitoring, food and drug safety testing, life science research, clinical application, chemical analysis and biomedical research. Microhole optical fiber with micro air holes can provide fitting space and circulation channel for the measurement of miniature volume liquid. Microhole optical fiber sensors have the characteristics of simple structure, enclosed environment, strong light and liquid interaction, which can meet the requirements of multi-parameter, high sensitivity and pollution-free measurement of minimal specimen. Here, we outline the cumulative introduction and the previous experimental research work on microhole fiber-optic sensors for nanoliter liquid, and ends with some conclusions and prospects. We hope this review can provide rigorous and organized literature to researchers/students for the basic understanding, trends, and practical utility of microhole fiber sensors.

Automated summary

Microhole optical fiber sensors have great potential in the measurement of nanoliter liquid, with their simple structure and high sensitivity meeting the requirements of various multi-parameter measurements.