期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 16, 期 21, 页码 9603-9609出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2008.09.023
关键词
Fibraurea tinctoria Lour; Furanoditerpenoids; Anti-inflammatory activities
资金
- National Science Council, Taiwan, Republic of China [95-2113-M-006-003]
Five new furanoditerpenoids, epi-8-hydroxycolumbin (1), fibaruretin B (2), C (3), E (5), and F (6), were isolated from the stems of Fibraurea tinctoria, as well as. fibaruretin D (4) from the natural source for the first time, and 39 known compounds. The structures (1-6) were elucidated on the basis of spectroscopic analysis. All the isolated furanoditerpenoids (1-16) were examined for their in vitro activity and some were in vivo anti-inflammatory activity. Compounds 8 and 9 showed significant anti-inflammatory action administered at a dose of 100 mg/kg of reducing carrageenan mice paw edema, whereas compound 7, 9, 10, 14, and 16 were more potent to inhibit NO production. The inhibitory effects of these compounds are dose-dependent (1-4 mu g/ml). (C) 2008 Elsevier Ltd. All rights reserved.
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