☆ 4.6 Review

Nirmatrelvir combined with ritonavir for preventing and treating COVID-19

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2022)

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Article Medicine, General & Internal

Pragmatic and open science-based solution to a current problem in the reporting of living systematic reviews

Maria-Inti Metzendorf et al.

Summary: Living systematic reviews (LSRs) are an approach to updating reviews in a timely manner. To address the lack of transparency in the evidence underlying published LSRs, a new method is proposed to report the living evidence surveillance process between published LSR versions.

BMJ EVIDENCE-BASED MEDICINE (2023)

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Article Medicine, General & Internal

Efficacy and safety of three new oral antiviral treatment (molnupiravir, fluvoxamine and Paxlovid) for COVID-19: a meta-analysis

Wen Wen et al.

Summary: This study conducted a meta-analysis on three new oral antivirals (molnupiravir, fluvoxamine, and Paxlovid) and their effects on mortality and hospitalization rates among COVID-19 patients. The results showed that these drugs were effective in reducing mortality and hospitalization rates by approximately 67%. Furthermore, the drugs did not increase adverse events, indicating good overall safety.

ANNALS OF MEDICINE (2022)

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Letter Virology

In the age of Omicron variant: Paxlovid raises new hopes of COVID-19 recovery

Zhonglei Wang et al.

JOURNAL OF MEDICAL VIROLOGY (2022)

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Letter Medicine, General & Internal

Efficacy of Antibodies and Antiviral Drugs against Covid-19 Omicron Variant

Emi Takashita et al.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Medicine, General & Internal

Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19

Jennifer Hammond et al.

Summary: In high-risk, unvaccinated adults, treatment of Covid-19 with nirmatrelvir plus ritonavir can significantly reduce the risk of hospitalization and death, with good safety profile.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Medicine, General & Internal

Early Remdesivir to Prevent Progression to Severe Covid-19 in Outpatients

R. L. Gottlieb et al.

Summary: In symptomatic, nonhospitalized high-risk Covid-19 patients, a 3-day course of remdesivir significantly reduced the risk of hospitalization or death compared to placebo, with acceptable safety profile.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Medicine, General & Internal

Effectiveness of Covid-19 Vaccines over a 9-Month Period in North Carolina

Dan-Yu Lin et al.

Summary: In a study conducted in North Carolina, Covid-19 vaccines were found to be highly effective in preventing hospitalization and death for up to 9 months after vaccination. The decrease in protection against infection over time was attributed to both declining immunity and the emergence of the delta variant.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Review Medicine, General & Internal

Omicron variant (B.1.1.529) of SARS-CoV-2: Mutation, infectivity, transmission, and vaccine resistance

Shi-Yan Ren et al.

Summary: This review summarizes the highly mutated regions, infectivity, transmission, vaccine breakthrough, and antibody resistance of the SARS-CoV-2 variant Omicron. Omicron is highly transmissible and may cause milder symptoms. Vaccines are less effective against the Omicron variant.

WORLD JOURNAL OF CLINICAL CASES (2022)

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Editorial Material Medicine, General & Internal

Cautious Optimism and Considerations for Health Providers and Patients: Oral Antiviral for Early Treatment of High-Risk Patients and Vaccines for Prevention of COVID-19

Jennifer Caceres et al.

AMERICAN JOURNAL OF MEDICINE (2022)

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Review Medicine, General & Internal

Ivermectin for preventing and treating COVID-19

Maria Popp et al.

Summary: The evidence on the efficacy and safety of ivermectin for treating COVID-19 is conflicting. Results suggest uncertainty in the effectiveness of ivermectin for treating severe cases and limited effects for mild cases.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2022)

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Article Biochemistry & Molecular Biology

Protease targeted COVID-19 drug discovery and its challenges: Insight into viral main protease (Mpro) and papain-like protease (PLpro) inhibitors

Sk. Abdul Amin et al.

Summary: This study focuses on the potential drug discovery for COVID-19 caused by SARS-CoV-2, specifically targeting viral protease enzymes. Challenges in developing effective protease inhibitors are discussed, with emphasis on the importance of oral delivery and optimizing pharmacokinetic properties for drug development. Combining adequate pharmacokinetic properties with coronavirus protease activity and selectivity may offer potential drug candidates in the future.

BIOORGANIC & MEDICINAL CHEMISTRY (2021)

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Article Primary Health Care

Willingness, beliefs, and barriers regarding the COVID-19 vaccine in Saudi Arabia: a multiregional cross-sectional study

Noura Altulahi et al.

Summary: The study revealed a promising willingness to accept the COVID-19 vaccine among the Saudi Arabian population, with positive beliefs and attitudes. However, a considerable proportion of the population was reluctant to accept the vaccine, with concerns mainly about vaccine side effects and safety. Some refusers mentioned that they would reconsider vaccination only if more studies reported on the safety and effectiveness of the vaccine. Providing information about vaccine safety and implementing health education programs are crucial for increasing public confidence in the vaccine.

BMC FAMILY PRACTICE (2021)

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Review Biochemical Research Methods

Overview of Targets and Potential Drugs of SARS-CoV-2 According to the Viral Replication

Yi Zhang et al.

Summary: This study updates potential targets and therapeutic drugs for SARS-CoV-2 from the perspective of the viral replication cycle, focusing on virus entry, proteases, and RdRp. Inhibitors for virus entry and RdRp are currently in clinical trials, while protease inhibitors require further in vivo and in vitro experiments to prove effectiveness against SARS-CoV-2.

JOURNAL OF PROTEOME RESEARCH (2021)

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Article Medicine, General & Internal

6-month consequences of COVID-19 in patients discharged from hospital: a cohort study (Publication with Expression of Concern. See vol. 401, pg. 90, 2023)

Chaolin Huang et al.

Summary: This study aimed to investigate the long-term health consequences of discharged COVID-19 patients and associated risk factors, particularly disease severity. Patients with more severe illness during hospitalization showed more severe impaired pulmonary diffusion capacities and abnormal chest imaging manifestations, highlighting the need for targeted interventions for long-term recovery.

LANCET (2021)

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Review Multidisciplinary Sciences

Population risk factors for severe disease and mortality in COVID-19: A global systematic review and meta-analysis

Adam Booth et al.

Summary: The study aims to analyze various clinical, demographic, and lifestyle variables associated with specific adverse outcomes in COVID-19 patients; by combining data from 17,860,001 patients across 14 countries, it identified many risk factors related to COVID-19, including age over 75, male sex, severe obesity, and active cancer.

PLOS ONE (2021)

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Article Multidisciplinary Sciences

An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19

Dafydd R. Owen et al.

Summary: PF-07321332, an orally bioavailable SARS-CoV-2 main protease inhibitor, has been discovered with in vitro pan-human coronavirus antiviral activity and excellent off-target selectivity and in vivo safety profiles. This new drug has shown promise in countering the threat of COVID-19 with its oral activity and safety in clinical trials.

SCIENCE (2021)

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Editorial Material Medicine, General & Internal

Combined treatment of molnupiravir and favipiravir against SARS-CoV-2 infection: One

Philippine Eloy et al.

EBIOMEDICINE (2021)

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Article Immunology

Vaccination willingness, vaccine hesitancy, and estimated coverage at the first round of COVID-19 vaccination in China: A national cross-sectional study

Chao Wang et al.

Summary: The survey in China showed that 67.1% of participants are willing to receive the COVID-19 vaccine, but 9.0% refuse it. Vaccine hesitancy is high at 35.5%, and the current vaccine coverage is only 34.4%, far from the level required for herd immunity.

VACCINE (2021)

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Editorial Material Infectious Diseases

Hospitalisation among vaccine breakthrough COVID-19 infections

Prerak Juthani et al.

LANCET INFECTIOUS DISEASES (2021)

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SARS-CoV-2 variants, spike mutations and immune escape

William T. Harvey et al.

Summary: The evolution of SARS-CoV-2 has been characterized by the emergence of mutations and variants that impact virus characteristics. Manufacturers are preparing for possible updates to vaccines in response to changes in the virus population, and it is crucial to monitor genetic and antigenic changes alongside experiments to understand the impacts of mutations.

NATURE REVIEWS MICROBIOLOGY (2021)

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Review Medicine, General & Internal

Antibiotics for the treatment of COVID-19

Maria Popp et al.

Summary: Antibiotics with potential antiviral and anti-inflammatory properties are being investigated in clinical trials for treatment of COVID-19, but current evidence does not conclusively support their efficacy or safety. More research is needed to verify whether antibiotics, including azithromycin, are beneficial for COVID-19 patients, particularly in the context of antimicrobial resistance.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2021)

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Review Medicine, General & Internal

Ivermectin for preventing and treating COVID-19

Maria Popp et al.

Summary: The current evidence regarding the efficacy and safety of ivermectin for treating or preventing COVID-19 is very low to low-certainty, with most completed studies being small and of low quality. Ongoing studies may provide more definitive answers. Overall, reliable evidence does not support the use of ivermectin for COVID-19 treatment or prevention without well-designed randomized trials.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2021)

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Editorial Material Medicine, General & Internal

Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention

Zunyou Wu et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Article Medicine, General & Internal

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang et al.

LANCET (2020)

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Editorial Material Multidisciplinary Sciences

Check for publication integrity before misconduct

Andrew Grey et al.

NATURE (2020)

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Article Infectious Diseases

Arbidol combined with LPV/r versus LPV/r alone against Corona Virus Disease 2019: A retrospective cohort study

Lisi Deng et al.

JOURNAL OF INFECTION (2020)

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Article Multidisciplinary Sciences

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

Wenhao Dai et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

Linlin Zhang et al.

SCIENCE (2020)

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Article Medicine, General & Internal

Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study

Christopher M. Petrilli et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

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Article Critical Care Medicine

Case characteristics, resource use, and outcomes of 10 021 patients with COVID-19 admitted to 920 German hospitals: an observational study

Christian Karagiannidis et al.

LANCET RESPIRATORY MEDICINE (2020)

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Article Public, Environmental & Occupational Health

Characteristics Associated with Hospitalization Among Patients with COVID-19-Metropolitan Atlanta, Georgia, March-April 2020

Marie E. Killerby et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2020)

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Editorial Material Medicine, Research & Experimental

SARS-CoV-2 SPIKE PROTEIN: an optimal immunological target for vaccines

Giovanni Salvatori et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

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Letter Infectious Diseases

Viral dynamics in mild and severe cases of COVID-19

Yang Liu et al.

LANCET INFECTIOUS DISEASES (2020)

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Article Infectious Diseases

A minimal common outcome measure set for COVID-19 clinical research

J. C. Marshall et al.

LANCET INFECTIOUS DISEASES (2020)

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Article Multidisciplinary Sciences

Factors associated with COVID-19-related death using OpenSAFELY

Elizabeth J. Williamson et al.

NATURE (2020)

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Review Multidisciplinary Sciences

The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): A systematic review and meta-analysis of 148 studies from 9 countries

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PLOS ONE (2020)

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Article Ethics

The carnage of substandard research during the COVID-19 pandemic: a call for quality

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JOURNAL OF MEDICAL ETHICS (2020)

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Manoj Kumar et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

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A living WHO guideline on drugs for covid-19

Francois Lamontagne et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

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Correction Biochemistry & Molecular Biology

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein (vol 180, 281.e1, 2020)

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CELL (2020)

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Transmissibility of COVID-19 depends on the viral load around onset in adult and symptomatic patients

Hitoshi Kawasuji et al.

PLOS ONE (2020)

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Jesse Fajnzylber et al.

NATURE COMMUNICATIONS (2020)

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Article Public, Environmental & Occupational Health

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Efrat Shadmi et al.

INTERNATIONAL JOURNAL FOR EQUITY IN HEALTH (2020)

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Rapid, point-of-care antigen and molecular-based tests for diagnosis of SARS-CoV-2 infection (Review)

Jacqueline Dinnes et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2020)

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RoB 2: a revised tool for assessing risk of bias in randomised trials

Jonathan A. C. Sterne et al.

BMJ-BRITISH MEDICAL JOURNAL (2019)

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BMJ OPEN (2016)

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PRISMA-Equity 2012 Extension: Reporting Guidelines for Systematic Reviews with a Focus on Health Equity

Vivian Welch et al.

PLOS MEDICINE (2012)

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GRADE guidelines: 3. Rating the quality of evidence

Howard Balshem et al.

JOURNAL OF CLINICAL EPIDEMIOLOGY (2011)

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Article Cell Biology

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TRIALS (2007)

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K Anand et al.

SCIENCE (2003)

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