Intrinsic protein disorder and conditional folding in AlphaFoldDB

Intrinsically disordered regions (IDRs) defying the traditional protein structure-function paradigm have been difficult to analyze. The availability of accurate structure predictions on a large scale in AlphaFoldDB offers a fresh perspective on IDR prediction. Here, we establish three baselines for IDR prediction from AlphaFoldDB models based on the recent CAID dataset. Surprisingly, AlphaFoldDB is highly competitive for predicting both IDRs and conditionally folded binding regions, demonstrating the plasticity of the disorder to structure continuum.

Automated summary

AlphaFoldDB provides a fresh perspective on predicting intrinsically disordered regions (IDRs) and conditionally folded binding regions, showing high competitiveness in these predictions and demonstrating the plasticity of the disorder to structure continuum.