期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 16, 期 24, 页码 10356-10362出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2008.10.012
关键词
Erythrina abyssinica; Flavanone; 2,2-Dimethylpyrano ring; PTP1B inhibitor
资金
- Ministry of Science and Technology and a Korea Science
- Korean government (MOST) [M10642140004-06N4214-00410]
Twelve new flavanones bearing a 2,2-dimethylpyrano ring were isolated from a MeOH extract of the stem bark of Erythrina abyssinica. Their structures were determined on the basis of spectroscopic (UV, CD, 1D and 2D NMR, HRMS) and physico-chemical analyses. Compounds 1, 3, 5, 6, 8, and 9 exhibited inhibitory effects on the enzyme activity of PTP1B in an in vitro assay with IC50 values ranging from 13.9 +/- 2.1 to 19.0 +/- 1.8 mu M. These results suggest that prenyl and methoxy groups on the B ring contribute to the inhibitory activity of flavanones against PTP1B. Crown copyright (C) 2008 Published by Elsevier Ltd. All rights reserved.
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