期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 16, 期 13, 页码 6641-6650出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2008.05.023
关键词
target gene delivery; polyamidoamine; RGD peptides; Staudinger ligation
资金
- Biotechnology and Biological Sciences Research Council [BBS/S/A/2003/10418] Funding Source: Medline
Two new methods for the modular synthesis of targeted gene delivery systems are reported. The PEGylated polyamidoamine DMEDA-PEG-DMEDA-(MBA-DMEDA)(n+1)-PEG-DMEDA 3 was sequentially modified to contain an integrin-binding peptide ligand via the Staudinger ligation. The conjugation of the ligand was achieved either before particle complexation (precomplexation) or after particle complexation (postcomplexation). Comparison of the two systems showed that postcomplexation strategy led to small and discrete toroidal nanoparticles whilst the precomplexation particles showed loose complexes. The targeted particles showed an increased uptake into cells compared to unmodified complexes however no significant increase in transfection was seen. (c) 2008 Elsevier Ltd. All rights reserved.
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