期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 16, 期 21, 页码 9471-9486出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2008.09.041
关键词
Alzheimer's disease; BACE-1 inhibitors; P1 modifications; Peptidomimetics
资金
- Medivir AB
Several BACE-1 inhibitors with low nanomolar level activities, encompassing a statine-based core structure with phenyloxymethyl- and benzyloxymethyl residues in the P1 position, are presented. The novel P1 modi. cation introduced to allow the facile exploration of the S1 binding pocket of BACE-1, delivered highly promising inhibitors. (C) 2008 Elsevier Ltd. All rights reserved.
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