期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 16, 期 5, 页码 2212-2225出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2007.11.078
关键词
autotaxin; ATX; phosphonates; LPA
资金
- NIGMS NIH HHS [R01 GM067958-02, R01 GM052722, R01 GM067958] Funding Source: Medline
Autotaxin (ATX) is an attractive pharmacological target due to its lysophospholipase D activity which leads to the production of lysophosphatidic acid (LPA). Blockage of ATX produced LPA by small molecules could be a potential anticancer chemotherapy. In our previous study, we have identified the two beta-hydroxy phosphonate analogs of LPA (compounds f17 and f18) as ATX inhibitors. With this work, we investigated alpha- and beta-substituted phosphonate analogs of LPA and evaluated them for ATX inhibitory activity. The stereochemistry of beta-hydroxy phosphonates was also studied. Published by Elsevier Ltd.
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