Ortho C-H Functionalization of 2-Arylimidazo [1,2-a]pyridines

C-H activation and functionalization is quite promising in recent days as the strategy offers a go-to general method for different bond formations and hence grants synthetic versatility. At the same time, imidazopyridine, a fused bicycle of imidazole moiety with pyridine ring, has a profound impact due to its ubiquitous and prodigious application in medicinal as well as material chemistry. The presence of N-1 atom in 2-arylImidazo[1,2-a]pyridine facilitates the coordination with metal catalysts leading to the formation of ortho-substituted products. This review summarizes all the articles on ortho C-H functionalization of 2-arylImidazo[1,2-a]pyridines published till August 2021.

Automated summary

C-H activation and functionalization is a promising strategy for synthetic versatility, while the fused bicycle of imidazole with pyridine, 2-arylImidazo[1,2-a]pyridine, has profound impact in medicinal and material chemistry. The N-1 atom in 2-arylImidazo[1,2-a]pyridine facilitates coordination with metal catalysts for ortho-substituted product formation. This review summarizes the research articles on ortho C-H functionalization of 2-arylImidazo[1,2-a]pyridines published until August 2021.