期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 16, 期 5, 页码 2676-2686出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2007.11.039
关键词
pseudouridine; uridine; homoserine; methylation; conformation
资金
- NIGMS NIH HHS [R01 GM054632-09, R29 GM054632, GM54632, R01 GM054632] Funding Source: Medline
A series of 3-substituted uridine and pseudouridine derivatives, based on the naturally occurring 3-(3-amino-3-carboxypropyl) modification, were synthesized. Their aqueous solution conformations were determined by using circular dichroism and NMR spectroscopy. Functional group composition and chain length were shown to have only a subtle influence on the distribution of syn/anti conformations of the modified nucleosides. The dominating factor appears to be the glycosidic linkage (C- vs. N-glycoside) in determining the nucleoside conformation. (C) 2007 Elsevier Ltd. All rights reserved.
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