期刊
BIOMOLECULES & THERAPEUTICS
卷 16, 期 4, 页码 343-350出版社
KOREAN SOC APPLIED PHARMACOLOGY
DOI: 10.4062/biomolther.2008.16.4.343
关键词
Scutellaria flavone; Behavior; Oroxylin A; ADHD; GABA
资金
- Sahmyook university
Oroxylin A is a flavonoid isolated from Scutellaria baicalensis, which is one of the most important medicinal herbs in traditional Korean medicine. In this study, we investigated the psychopharmacological activities of oroxylin A using the open field, rota-rod, balanced wire and plus-maze tests in Spontaneously Hypertensive Rats (SHR) and Wistar Kyoto Rats (WKY). Oroxylin A reduced hyperactivity in SHR (ADHD animal model) although it tended to increase locomotor activity in WKY Methylphenidate did not reduce hyperactivity. Oroxylin A alleviated impulsive behaviors such as rearing, the percentage of moving time to the central area and the tendency to move into an unstable condition (open area in elevated plus-maze). Methylphenidate also reduced the percentage of staying time in the central area and the tendency to move into an unstable condition. Both oroxylin A and methylphenidate enhanced motor attention in SHR and WKY. Oroxylin A antagonized the muscimol (GABA(A) receptor agonist)-induced Cl(-)current and its action was similar to that of bicuculline (GABAA receptor antagonist). The effects of oroxylin A may be caused by the antagonism at the GABAA receptor. Thus, oroxylin A may be a candidate of drug for treatment of ADHD.
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