4.1 Review

Bottom-Up versus Top-Down Strategies for Morphology Control in Polymer-Based Biomedical Materials

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Exploring the Impact of Morphology on the Properties of Biodegradable Nanoparticles and Their Diffusion in Complex Biological Medium

Roxane Ridolfo et al.

Summary: The morphology and surface chemistry of nanoparticles play a crucial role in their efficacy in therapeutic applications, with high aspect ratio shapes showing enhanced properties in terms of cell uptake, drug release, and diffusion.

BIOMACROMOLECULES (2021)

Article Chemistry, Multidisciplinary

Versatile Phospholipid Assemblies for Functional Synthetic Cells and Artificial Tissues

Xuejing Wang et al.

Summary: Synthetic cells constructed from nonliving building blocks such as phospholipids can mimic cellular properties and structures, showing potential for biomedical applications.

ADVANCED MATERIALS (2021)

Review Chemistry, Multidisciplinary

Self-Assembly of Photoresponsive Molecular Amphiphiles in Aqueous Media

Shaoyu Chen et al.

Summary: Amphiphilic molecules with the ability to self-assemble in aqueous environments exhibit a wide range of structures and functions. By incorporating photoresponsive motifs, these molecules can be designed to create non-invasive supramolecular systems that respond to light in water. The delicate balance between structural design, self-assembling conditions, and external stimuli allows for the development of dynamic functions in isotropic and anisotropic systems, leading to applications in soft adaptive materials and controlled delivery systems.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Nanoscience & Nanotechnology

Pickering Emulsions Based on Wax and Halloysite Nanotubes: An Ecofriendly Protocol for the Treatment of Archeological Woods

Lorenzo Lisuzzo et al.

Summary: A novel green protocol has been developed for the consolidation and protection of waterlogged archeological woods using wax microparticles, in which halloysite nanotubes (HNTs) based Pickering emulsions were designed. The prepared hybrid systems showed improved mechanical performance and thermal properties, demonstrating potential for the preservation of wooden artworks and shipwrecks.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Polymer Science

PhotoATRP-Induced Self-Assembly (PhotoATR-PISA) Enables Simplified Synthesis of Responsive Polymer Nanoparticles in One-Pot

Ali Shahrokhinia et al.

Summary: Photo-controlled atom transfer radical polymerization (PhotoATRP) was used to achieve polymerization-induced self-assembly (PISA) mediated by UV light for the first time, resulting in core-cross-linked nanoparticles (NPs). By sequentially extending PGMA chains and incorporating CBMA for core cross-linking, multifunctional copolymer NPs were obtained with temporal control through UV light switching. Additionally, the core cross-linking with disulfide bonds in CBMA allowed for stimulus-triggered dissociation of nanoparticles at acidic pH.

MACROMOLECULES (2021)

Article Nanoscience & Nanotechnology

Self-assembly of aramid amphiphiles into ultra-stable nanoribbons and aligned nanoribbon threads

Ty Christoff-Tempesta et al.

Summary: The study introduces a small-molecule platform called aramid amphiphile, which exhibits stability and can self-assemble in water to form nanoribbons with high strength and toughness. These nanoribbons can be further organized into dry threads that can support 200 times their weight, extending small-molecule self-assembly to macroscopic materials and enabling new possibilities for solid-state applications.

NATURE NANOTECHNOLOGY (2021)

Review Biotechnology & Applied Microbiology

Engineering precision nanoparticles for drug delivery

Michael J. Mitchell et al.

Summary: The development of nanoparticles has shown promising clinical applications, overcoming the limitations of therapeutic interventions and biological barriers. Precision therapies have enhanced treatment efficacy through personalized interventions. Advancements in nanoparticle design aim to optimize drug delivery, improving efficacy in general applications and enabling tailored designs for precision applications.

NATURE REVIEWS DRUG DISCOVERY (2021)

Review Chemistry, Multidisciplinary

Synthesis and applications of anisotropic nanoparticles with precisely defined dimensions

Amanda K. Pearce et al.

Summary: Shape and size are crucial factors in determining material properties, and the introduction of shape anisotropy at the nanoscale is a potent way to access new properties and functionalities. Recent advancements have allowed for precise control over the morphology and dimensions of anisotropic nanoparticles, leading to the development of materials with unique properties.

NATURE REVIEWS CHEMISTRY (2021)

Review Chemistry, Multidisciplinary

Harnessing Endogenous Stimuli for Responsive Materials in Theranostics

Alexander B. Cook et al.

Summary: Materials that respond to endogenous stimuli play a crucial role in enhancing spatiotemporal control in biomedical applications. These materials can be designed to undergo morphological or chemical changes in response to specific biological cues, offering promising opportunities for improving therapeutic efficacy and developing personalized healthcare systems. They can be engineered across different length scales to respond to endogenous signals such as enzymes, pH, glucose, and hold great potential for a wide range of applications.

ACS NANO (2021)

Review Pharmacology & Pharmacy

Elongated self-assembled nanocarriers: From molecular organization to therapeutic applications

Julie Mougin et al.

Summary: Self-assembled cylindrical aggregates made of amphiphilic molecules have unique physico-chemical properties that are valuable for industrial applications and potential therapeutic purposes, such as designing elongated drug nanocarriers. Current research focuses on exploring the main forces driving the unidirectional growth of nanodevices and aiming to minimize unnecessary side effects and potential toxicity by forming pure nanodrugs.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Article Chemistry, Multidisciplinary

Superstructured Biomaterials Formed by Exchange Dynamics and Host-Guest Interactions in Supramolecular Polymers

Alexandra N. Edelbrock et al.

Summary: The study reports a supramolecular system where interactions between peptide amphiphiles and beta-cyclodextrin with adamantane lead to the formation of a mechanically robust hydrogel with highly porous architecture, which can be 3D printed and exhibits significant bioactivity towards neurons. This nanostructured hydrogel based on supramolecular assembly has potential applications in neuronal research and biomaterial design.

ADVANCED SCIENCE (2021)

Review Immunology

Modulation of Immune Responses by Particle Size and Shape

Maksim V. Baranov et al.

Summary: The size, shape, rigidity, and surface roughness of pathogens are important parameters affecting cellular uptake and immune responses, particularly in inflammasome activation and T cell activation. Understanding how the physical properties of particles influence immune responses can assist in the design of more effective vaccines.

FRONTIERS IN IMMUNOLOGY (2021)

Article Engineering, Biomedical

Bioinspired Polymeric High-Aspect-Ratio Particles with Asymmetric Janus Functionalities

Joel A. Finbloom et al.

Summary: This article introduces a method for preparing nonspherical Janus particles inspired by high-aspect-ratio filamentous bacteriophage, made from polycaprolactone polymers using standard methods. These particles have branching morphologies and demonstrate directional functionalization during fabrication.

ADVANCED NANOBIOMED RESEARCH (2021)

Article Polymer Science

Nano-assemblies with core-forming hydrophobic polypeptide via polymerization-induced self-assembly (PISA)

T. P. Tuyen Dao et al.

Summary: This study aims to produce self-assembled structures with hydrophobic polypeptide cores using RAFT-mediated PISA. Different hydrophobic monomers were polymerized under varying conditions to form diblock copolymer nano objects, resulting in a range of morphologies influenced by the peptides self-assembling core.

POLYMER CHEMISTRY (2021)

Article Chemistry, Multidisciplinary

3D Printing of Strong and Tough Double Network Granular Hydrogels

Matteo Hirsch et al.

Summary: Many soft natural tissues possess unique mechanical properties achieved through complex interactions between structure and composition. To address the lack of control in soft synthetic materials, a novel 3D printing approach called double network granular hydrogels (DNGHs) has been introduced. These DNGHs are stiff enough to support high tensile loads and significantly tougher than pure polymeric networks. This ink allows for the printing of strong and tough objects with high shape fidelity, opening up new possibilities for soft robotic applications.

ADVANCED FUNCTIONAL MATERIALS (2021)

Review Chemistry, Multidisciplinary

Branched and Dendritic Polymer Architectures: Functional Nanomaterials for Therapeutic Delivery

Alexander B. Cook et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

Review Chemistry, Multidisciplinary

Supramolecular and Hybrid Bonding Polymers

Samuel I. Stupp et al.

ISRAEL JOURNAL OF CHEMISTRY (2020)

Article Chemistry, Multidisciplinary

Engineering shape-defined PLGA microPlates for the sustained release of anti-inflammatory molecules

Martina Di Francesco et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Article Chemistry, Multidisciplinary

Multiphase Complex Coacervate Droplets

Tiemei Lu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Review Engineering, Multidisciplinary

Current Trends in Pickering Emulsions: Particle Morphology and Applications

Danae Gonzalez Ortiz et al.

ENGINEERING (2020)

Article Biochemistry & Molecular Biology

Wormlike Nanovector with Enhanced Drug Loading Using Blends of Biodegradable Block Copolymers

Roxane Ridolfo et al.

BIOMACROMOLECULES (2020)

Article Biochemistry & Molecular Biology

3D-Printing of Structure-Controlled Antigen Nanoparticles for Vaccine Delivery

Akihiro Nishiguchi et al.

BIOMACROMOLECULES (2020)

Review Chemistry, Multidisciplinary

Bioprinting: From Tissue and Organ Development to in Vitro Models

Carlos Mota et al.

CHEMICAL REVIEWS (2020)

Article Multidisciplinary Sciences

Controlled packing and single-droplet resolution of 3D-printed functional synthetic tissues

Alessandro Alcinesio et al.

NATURE COMMUNICATIONS (2020)

Article Chemistry, Multidisciplinary

Multi-responsive hydrogel structures from patterned droplet networks

Florence G. Downs et al.

NATURE CHEMISTRY (2020)

Article Chemistry, Multidisciplinary

Proapoptotic Peptide Brush Polymer Nanoparticles via Photoinitiated Polymerization-Induced Self-Assembly

Hao Sun et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Review Biochemistry & Molecular Biology

Fundamentals of Emulsion Polymerization

Peter A. Lovell et al.

BIOMACROMOLECULES (2020)

Article Chemistry, Multidisciplinary

Supramolecular Exchange among Assemblies of Opposite Charge Leads to Hierarchical Structures

James R. Wester et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Article Polymer Science

Self-Assembling Peptide-Polymer Nano-Objects via Polymerization-Induced Self-Assembly

T. P. Tuyen Dao et al.

MACROMOLECULES (2020)

Review Chemistry, Physical

Pickering-Ramsden emulsions stabilized with chemically and morphologically anisotropic particles

Yasutaka Iwashita

CURRENT OPINION IN COLLOID & INTERFACE SCIENCE (2020)

Article Materials Science, Biomaterials

Effect of Nanoparticle Composition, Size, Shape, and Stiffness on Penetration Across the Blood-Brain Barrier

Tyler D. Brown et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

Review Polymer Science

Design of materials with supramolecular polymers

Tristan D. Clemons et al.

PROGRESS IN POLYMER SCIENCE (2020)

Review Engineering, Biomedical

Interfacial nanoarchitectonics for responsive cellular biosystems

Jingwen Song et al.

MATERIALS TODAY BIO (2020)

Article Chemistry, Multidisciplinary

Spontaneous, solvent-free entrapment of siRNA within lipid nanoparticles

Jayesh A. Kulkarni et al.

NANOSCALE (2020)

Article Chemistry, Physical

Catalytically propelled 3D printed colloidal microswimmers

Rachel P. Doherty et al.

SOFT MATTER (2020)

Article Chemistry, Multidisciplinary

Poly(ethylene glycol) based nanotubes for tuneable drug delivery to glioblastoma multiforme

Majed Alghamdi et al.

NANOSCALE ADVANCES (2020)

Article Biotechnology & Applied Microbiology

Size, shape, and flexibility influence nanoparticle transport across brain endothelium under flow

Maksymilian Nowak et al.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2020)

Review Engineering, Manufacturing

Projection micro stereolithography based 3D printing and its applications

Qi Ge et al.

INTERNATIONAL JOURNAL OF EXTREME MANUFACTURING (2020)

Article Biochemical Research Methods

Soft temperature-responsive microgels of complex shape in stop-flow lithography

Hanna J. M. Wolff et al.

LAB ON A CHIP (2020)

Article Polymer Science

Enzyme-Responsive Polymer Nanoparticles via Ring-Opening Metathesis Polymerization-Induced Self-Assembly

Daniel B. Wright et al.

MACROMOLECULAR RAPID COMMUNICATIONS (2019)

Review Polymer Science

Controlling Nanomaterial Size and Shape for Biomedical Applications via Polymerization-Induced Self-Assembly

Song Yang Khor et al.

MACROMOLECULAR RAPID COMMUNICATIONS (2019)

Article Chemistry, Multidisciplinary

Nanotube-Mediated Path to Protocell Formation

Elif S. Koksal et al.

ACS NANO (2019)

Article Chemistry, Multidisciplinary

Mimicking Cellular Compartmentalization in a Hierarchical Protocell through Spontaneous Spatial Organization

Alexander F. Mason et al.

ACS CENTRAL SCIENCE (2019)

Article Biochemistry & Molecular Biology

Synthetic 3D PEG-Anisogel Tailored with Fibronectin Fragments Induce Aligned Nerve Extension

Christopher Licht et al.

BIOMACROMOLECULES (2019)

Review Chemistry, Multidisciplinary

Self-Assembling Peptide-Based Nanoarchitectonics

Luyang Zhao et al.

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN (2019)

Article Chemistry, Multidisciplinary

3D-Printed Biodegradable Microswimmer for Theranostic Cargo Delivery and Release

Hakan Ceylan et al.

ACS NANO (2019)

Article Chemistry, Multidisciplinary

Polyhedral Liquid Marbles

Florian Geyer et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

Article Nanoscience & Nanotechnology

Hierarchical Microplates as Drug Depots with Controlled Geometry, Rigidity, and Therapeutic Efficacy

Martina Di Francesco et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

Article Chemistry, Multidisciplinary

Self-Assembled Breathing Grana-Like Cisternae Stacks

Qingchuan Li et al.

ADVANCED MATERIALS (2018)

Article Polymer Science

Aqueous-Phase Ring-Opening Metathesis Polymerization-Induced Self-Assembly

Daniel B. Wright et al.

ACS MACRO LETTERS (2018)

Article Chemistry, Multidisciplinary

Emulsion Droplets Stabilized by Close-Packed Janus Regular Polygonal Particles

Ryotaro Koike et al.

LANGMUIR (2018)

Article Biochemistry & Molecular Biology

RAFT Emulsion Polymerization as a Platform to Generate Well-Defined Biocompatible Latex Nanoparticles

Pratik Gurnani et al.

MACROMOLECULAR BIOSCIENCE (2018)

Article Chemistry, Multidisciplinary

Soft and flexible poly(ethylene glycol) nanotubes for local drug delivery

B. Newland et al.

NANOSCALE (2018)

Article Chemistry, Analytical

Design of Hydrogel Particle Morphology for Rapid Bioassays

Sarah J. Shapiro et al.

ANALYTICAL CHEMISTRY (2018)

Article Chemistry, Physical

Programmed assembly of synthetic protocells into thermoresponsive prototissues

Pierangelo Gobbo et al.

NATURE MATERIALS (2018)

Article Multidisciplinary Sciences

Reversible self-assembly of superstructured networks

Ronit Freeman et al.

SCIENCE (2018)

Review Chemistry, Multidisciplinary

Controlling the morphology of copolymeric vectors for next generation nanomedicine

David S. Williams et al.

JOURNAL OF CONTROLLED RELEASE (2017)

Article Biotechnology & Applied Microbiology

Deformable Discoidal Polymeric Nanoconstructs for the Precise Delivery of Therapeutic and Imaging Agents

Anna Lisa Palange et al.

MOLECULAR THERAPY (2017)

Article Chemistry, Multidisciplinary

Nerve Cells Decide to Orient inside an Injectable Hydrogel with Minimal Structural Guidance

Jonas C. Rose et al.

NANO LETTERS (2017)

Article Ophthalmology

Pharmacokinetic aspects of retinal drug delivery

Eva M. del Amo et al.

PROGRESS IN RETINAL AND EYE RESEARCH (2017)

Article Multidisciplinary Sciences

Formation of non-spherical polymersomes driven by hydrophobic directional aromatic perylene interactions

Chin Ken Wong et al.

NATURE COMMUNICATIONS (2017)

Article Chemistry, Multidisciplinary

Biocompatible Amphiphilic Hydrogel-Solid Dimer Particles as Colloidal Surfactants

Dong Chen et al.

ACS NANO (2017)

Article Chemistry, Multidisciplinary

Co-opting Moore's law: Therapeutics, vaccines and interfacially active particles manufactured via PRINT®

Joseph M. DeSimone

JOURNAL OF CONTROLLED RELEASE (2016)

Article Chemistry, Multidisciplinary

Role of nanoparticle size, shape and surface chemistry in oral drug delivery

Amrita Banerjee et al.

JOURNAL OF CONTROLLED RELEASE (2016)

Article Polymer Science

A Critical Appraisal of RAFT-Mediated Polymerization-Induced Self Assembly

Sarah L. Canning et al.

MACROMOLECULES (2016)

Review Biotechnology & Applied Microbiology

The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction

Nazanin Hoshyar et al.

NANOMEDICINE (2016)

Article Chemistry, Physical

Energy landscapes and functions of supramolecular systems

Faifan Tantakitti et al.

NATURE MATERIALS (2016)

Article Multidisciplinary Sciences

Super-resolution microscopy reveals structural diversity in molecular exchange among peptide amphiphile nanofibres

Ricardo M. P. da Silva et al.

NATURE COMMUNICATIONS (2016)

Article Chemistry, Multidisciplinary

Pickering emulsions stabilized by shape-controlled silica microrods

Fangli Lou et al.

RSC ADVANCES (2016)

Article Multidisciplinary Sciences

Light-activated communication in synthetic tissues

Michael J. Booth et al.

SCIENCE ADVANCES (2016)

Article Chemistry, Multidisciplinary

Soft Patchy Particles of Block Copolymers from Interface-Engineered Emulsions

Kang Hee Ku et al.

ACS NANO (2015)

Article Biotechnology & Applied Microbiology

Principles of nanoparticle design for overcoming biological barriers to drug delivery

Elvin Blanco et al.

NATURE BIOTECHNOLOGY (2015)

Article Polymer Science

Photo-PISA: Shedding Light on Polymerization-Induced Self-Assembly

Jianbo Tan et al.

ACS MACRO LETTERS (2015)

Article Chemistry, Multidisciplinary

pH-Sensitive Tubular Polymersomes: Formation and Applications in Cellular Delivery

James D. Robertson et al.

ACS NANO (2014)

Article Chemistry, Multidisciplinary

Polymerization-Induced Self-Assembly of Block Copolymer Nano-objects via RAFT Aqueous Dispersion Polymerization

Nicholas J. Warren et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

Article Chemistry, Multidisciplinary

Particle Shape Anisotropy in Pickering Emulsions: Cubes and Peanuts

Julius W. J. de Folter et al.

LANGMUIR (2014)

Article Biochemistry & Molecular Biology

Permeability Effects on the Efficiency of Antioxidant Nanoreactors

Iria Louzao et al.

BIOMACROMOLECULES (2013)

Article Chemistry, Multidisciplinary

Cationic Polyelectrolyte-Stabilized Nanoparticles via RAFT Aqueous Dispersion Polymerization

M. Semsarilar et al.

LANGMUIR (2013)

Article Multidisciplinary Sciences

Guided hierarchical co-assembly of soft patchy nanoparticles

Andre H. Groeschel et al.

NATURE (2013)

Article Multidisciplinary Sciences

Targeted delivery of proapoptotic peptides to tumor-associated macrophages improves survival

Maryelise Cieslewicz et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Chemistry, Multidisciplinary

Polymersome Colloidosomes for Enzyme Catalysis in a Biphasic System

Zhipeng Wang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)

Review Chemistry, Multidisciplinary

Polymersomes for drug delivery: Design, formation and characterization

Jung Seok Lee et al.

JOURNAL OF CONTROLLED RELEASE (2012)

Article Multidisciplinary Sciences

Precise hierarchical self-assembly of multicompartment micelles

Andre H. Groeschel et al.

NATURE COMMUNICATIONS (2012)

Article Chemistry, Multidisciplinary

Mechanistic Insights for Block Copolymer Morphologies: How Do Worms Form Vesicles?

Adam Blanazs et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

Article Chemistry, Multidisciplinary

Size and shape effects in the biodistribution of intravascularly injected particles

P. Decuzzi et al.

JOURNAL OF CONTROLLED RELEASE (2010)

Review Chemistry, Multidisciplinary

The Synthesis and Assembly of Polymeric Microparticles Using Microfluidics

Dhananjay Dendukuri et al.

ADVANCED MATERIALS (2009)

Article Chemistry, Multidisciplinary

Stop-Flow Lithography for the Production of Shape-Evolving Degradable Microgel Particles

Dae Kun Hwang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)

Review Chemistry, Multidisciplinary

Intravascular Delivery of Particulate Systems: Does Geometry Really Matter?

Paolo Decuzzi et al.

PHARMACEUTICAL RESEARCH (2009)

Review Nanoscience & Nanotechnology

Top-down particle fabrication: control of size and shape for diagnostic imaging and drug delivery

Dorian A. Canelas et al.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2009)

Article Biochemical Research Methods

Shape effects of nanoparticles conjugated with cell-penetrating peptides (HIV Tat PTD) on CHO cell uptake

Ke Zhang et al.

BIOCONJUGATE CHEMISTRY (2008)

Article Biophysics

The receptor-mediated endocytosis of nonspherical particles

P. Decuzzi et al.

BIOPHYSICAL JOURNAL (2008)

Article Multidisciplinary Sciences

The effect of particle design on cellular internalization pathways

Stephanie E. A. Gratton et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Chemistry, Multidisciplinary

Nanofabricated particles for engineered drug therapies:: A preliminary Biodistribution study of PRINT ™ nanoparticles

Stephanie E. A. Gratton et al.

JOURNAL OF CONTROLLED RELEASE (2007)

Article Nanoscience & Nanotechnology

Shape effects of filaments versus spherical particles in flow and drug delivery

Yan Geng et al.

NATURE NANOTECHNOLOGY (2007)

Article Chemistry, Physical

Continuous-flow lithography for high-throughput microparticle synthesis

D Dendukuri et al.

NATURE MATERIALS (2006)

Article Multidisciplinary Sciences

Role of target geometry in phagocytosis

JA Champion et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Chemistry, Multidisciplinary

Direct fabrication and harvesting of monodisperse, shape-specific nanobiomaterials

JP Rolland et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)

Article Chemistry, Multidisciplinary

Amphiphilic Janus micelles with polystyrene and poly(methacrylic acid) hemispheres

R Erhardt et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)