期刊
BIOMOLECULAR NMR ASSIGNMENTS
卷 6, 期 1, 页码 51-55出版社
SPRINGER
DOI: 10.1007/s12104-011-9324-3
关键词
alpha-Synuclein; Fibrils; Solid-state NMR; Assignments; Secondary structure
资金
- Agence Nationale de la Recherche [ANR-07-PCVI-0013-03, ANR-PCV08 321323, ANR08-PCVI-0022-02]
- ETH Zurich
- Swiss National Science Foundation [200020_124611]
- Era-Net Neuron (project MIPROTRAN) [ANR-08-NEUR-001-01]
- Centre National de la Recherche Scientifique
- European Commission [Bio-NMR 261863]
- Agence Nationale de la Recherche (ANR) [ANR-07-PCVI-0013] Funding Source: Agence Nationale de la Recherche (ANR)
Parkinson's disease is amongst the most frequent and most devastating neurodegenerative diseases. It is tightly associated with the assembly of proteins into high-molecular weight protein species, which propagate between neurons in the central nervous system. The principal protein involved in this process is a-synuclein which is a structural component of the Lewy bodies observed in diseased brain. We here present the solid-state NMR sequential assignments of a new fibrillar form of this protein, the first one with a well-ordered and rigid N-terminal part.
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