期刊
BIOMOLECULAR NMR ASSIGNMENTS
卷 3, 期 1, 页码 49-52出版社
SPRINGER
DOI: 10.1007/s12104-008-9139-z
关键词
Complement; Membrane attack complex; MAC; C7; Factor I module; FIM; NMR; Resonance assignment
资金
- Medical Research Council of the U. K. [G0500940]
- The Wellcome Trust
- National Institute of Health [GM29831]
- MRC [G0500940] Funding Source: UKRI
- Medical Research Council [G0500940] Funding Source: researchfish
The carboxy terminus of human complement component C7 comprises two Factor I-like Modules (FIMs) which are essential for formation of the Membrane Attack Complex, the terminal pathway of the innate immune system. C7-FIMs is a 16.9 kDa, recombinant, disulphide-rich, protein encompassing this C-terminal domain. Using conventional triple resonance experiments 93% of the H-1, N-15 and C-13 assignment has been achieved, accounting for all assignment apart from a flexible N-terminus cloning artefact and an undefined loop. The chemical shifts have been deposited in the BioMagResBank; Accession No. 15996.
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