期刊
BIOMICROFLUIDICS
卷 6, 期 2, 页码 -出版社
AMER INST PHYSICS
DOI: 10.1063/1.3701566
关键词
-
资金
- National Institutes of Health (NIH) [1DP2OD007209-01]
- National Science Foundation
- US Department of Agriculture (USDA/NRI)
- Air Force Office of Scientific Research (AFOSR)
- Penn State Center for Nanoscale Science (MRSEC)
In this work, we demonstrate an integrated, single-layer, miniature flow cytometry device that is capable of multi-parametric particle analysis. The device integrates both particle focusing and detection components on-chip, including a microfluidic drifting based three-dimensional (3D) hydrodynamic focusing component and a series of optical fibers integrated into the microfluidic architecture to facilitate on-chip detection. With this design, multiple optical signals (i.e., forward scatter, side scatter, and fluorescence) from individual particles can be simultaneously detected. Experimental results indicate that the performance of our flow cytometry chip is comparable to its bulky, expensive desktop counterpart. The integration of on-chip 3D particle focusing with on-chip multi-parametric optical detection in a single-layer, mass-producible microfluidic device presents a major step towards low-cost flow cytometry chips for point-of-care clinical diagnostics. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.3701566]
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据