期刊
BIOMICROFLUIDICS
卷 6, 期 4, 页码 -出版社
AMER INST PHYSICS
DOI: 10.1063/1.4757968
关键词
bioMEMS; biosensors; chemical sensors; finite difference time-domain analysis; gold; island structure; lab-on-a-chip; microfluidics; microsensors; molecular biophysics; nanostructured materials; optical sensors; proteins; ultraviolet spectra; visible spectra; wave propagation
资金
- Ministere du Developpement economique, innovation et exportation (MDEIE) Quebec
- Valeo Gestion, Montreal, Canada
Integration of nano-materials in optical microfluidic devices facilitates the realization of miniaturized analytical systems with enhanced sensing abilities for biological and chemical substances. In this work, a novel method of integration of gold nano-islands in a silica-on-silicon-polydimethylsiloxane microfluidic device is reported. The device works based on the nano-enhanced evanescence technique achieved by interacting the evanescent tail of propagating wave with the gold nano-islands integrated on the core of the waveguide resulting in the modification of the propagating UV-visible spectrum. The biosensing ability of the device is investigated by finite-difference time-domain simulation with a simplified model of the device. The performance of the proposed device is demonstrated for the detection of recombinant growth hormone based on antibody-antigen interaction. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4757968]
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